Arkansas Claude Pepper Older Americans Independence Center at UAMS

阿肯色州OAIC在UAMS的主题是“关于衰老和疾病中心脏和骨骼肌功能障碍的翻译研究”。 阿肯色州OAIC的主要目标是 1)促进既提供机制又提供机制的研究 了解骨骼肌功能和心肌功能随年龄增长而下降的基础，并将从这些研究中学到的知识转化为最终将影响老年人营养建议和护理标准的干预研究； 2)引入最先进的蛋白质代谢研究方法，以便更好地使基于分子的基础研究最终将结果转化为旨在改善老年人结果的临床试验； 3)使用新的营养干预措施预防和治疗心肌和骨骼肌无力； 4)培训新一代老年医生和老年医学专家，通过治疗性营养干预提高美国老年人的功能独立性。 这些目标将通过以下具体目标实现。 具体目标1.在UAMS调查人员中提供科学、智力和创新方面的领导。 具体目标2.通过研究人员之间的合作和互动，促进基础研究和临床研究之间的转换，以提高我们对导致骨骼肌功能和心肌功能随年龄下降的机制的理解。干预措施将包括但不限于治疗性营养补充。 具体目标3.在分析心肌和骨骼肌无力的蛋白质代谢和营养干预方面，鼓励采用新技术和新方法和途径。 具体目标4.作为向其他机构(特别是OUHSC和其他OAIC)提供关于提案中心主题的技术和专业知识的建议和合作的来源，并促进多学科和跨学科战略。 具体目标5.为未来的研究带头人提供职业发展，增加招聘年轻和成熟的老龄研究人员，同时强调招募少数族裔加入UAMS。 具体目标6.扩大研究范围，最大限度地将少数群体代表纳入所有研究。这一OAIC将有助于将创新的肌肉研究转化为改善护理，包括为农村老年人提供护理。

The theme of the Arkansas OAIC at UAMS is "Translational research on cardiac and skeletal muscle dysfunction in aging and disease." The main goals of the Arkansas OAIC are 1) To promote research that will both provide a mechanistic understanding of the basis for declining skeletal muscle function and myocardial performance with advancing age and translate what is learned from those studies to intervention studies that will ultimately affect nutritional recommendations and standard of care in the elderly; 2) To introduce state-of-the-art methodologies for studying protein metabolism to better enable basic molecular-based studies to ultimately translate the findings to the performance of clinical trials aimed at improving outcomes in elderly individuals; 3) use novel nutritional interventions in the prevention and treatment of cardiac and skeletal muscle weakness; 4) To train a new generation of geriatricians and gerontologists in improving functional independence of older Americans through therapeutic nutritional interventions. These goals will be achieved via the following Specific Aims. Specific Aim 1. Provide scientific, intellectual, and innovation leadership among UAMS investigators. Specific Aim 2. Stimulate translation between basic and clinical research through collaboration and interaction among investigators to improve our understanding of mechanisms contributing to declining skeletal muscle function and myocardial performance with age. Interventions will include, but not be limited to, therapeutic nutrient supplementation. Specific Aim 3. Stimulate incorporation of emerging technologies and novel methods and approaches in analyzing protein metabolism and nutritional interventions for cardiac and skeletal muscle weakness. Specific Aim 4. Serve as a source of advice and collaboration to other institutions (especially OUHSC and other OAICs) regarding technology and expertise in the center theme of the proposal and facilitate multi- and interdisciplinary strategies. Specific Aim 5. Provide career development for future research leaders by increasing the recruitment of young and established investigators In aging, while emphasizing recruitment of minorities to UAMS. Specific Aim 6. Expand the research outreach to maximally include minority representation in all studies. This OAIC would help translate innovative muscle research to improve care, including for the rural elderly.