Predoctoral Training Program in Virology

描述(由申请人提供)：耶鲁大学病毒学培训计划的目标是为博士后学员提供必要的知识和研究基础，使其成为独立的科学家/教育工作者，研究病毒的分子生物学、宿主对病毒的反应及其在人类疾病中的作用。病毒学培训计划将在高度协作、互动的环境中进行严格的研究培训与现代病毒学、普通微生物学、免疫学和相关学科的全面学术课程相结合。该计划提供几乎所有方面的培训，病毒遗传学，分子， 病毒的细胞和结构生物学，以及细胞和生物水平上的病毒与宿主的相互作用。特别强大的领域包括病毒组件的结构生物学， 病毒转化、病毒进入、传播和复制，以及对病毒的适应性和先天免疫反应，包括一些具有生物防御兴趣的精选病原体。作为一个整体，19名病毒学计划培训员在研究成就和培训方面有着出色的记录，其中许多人是各自领域的国内或国际领先者。这些教员在12个不同的耶鲁大学系担任主要职务，目前有50名博士前病毒学实习生在他们的实验室工作。获得博士学位的博士前培训包括微生物学和/或免疫学的正式课程工作，以及生物学其他领域的工作、研究轮换、教学和前三个学期的资格考试，论文研究从第一年开始，并在完成资格考试后成为主要活动重点。在研究的方法、逻辑和负责任的行为方面进行强化培训，并辅之以各种科学互动的机会。获得博士学位的时间中位数为5.7年。耶鲁大学研究生院和医学院以及病毒学培训师作出了广泛努力，以吸引和留住来自不同背景的学员，特别是代表不足的少数群体。本申请申请每年继续资助四名博士前实习生。受训者将由这笔补助金资助，最长为两年。

DESCRIPTION (provided by applicant): The goal of the Yale Virology Training Program is to equip predoctoral trainees with the intellectual and research foundations necessary to become independent scientists/educators investigating the molecular biology of viruses, host responses to them, and their roles in human disease. The Virology Training Program combines rigorous research training in a highly collaborative, interactive environment with a thorough academic program of instruction in modern virology, general microbiology, immunology and related disciplines. The program offers training in virtually all aspects of viral genetics, the molecular, cellular and structural biology of viruses, as well as virus-host interactions at the cellular and organismal levels. Areas of particular strength include the structural biology of viral components, viral transformation, viral entry, trafficking and replication, and the adaptive and innate immune response to viruses, including a number of select agent pathogens of biodefense interest. As a group, the 19 Virology Program trainers have an outstanding record of research accomplishment and training and many are national or international leaders in their fields. These faculty have primary appointments in 12 different Yale departments and currently have 50 predoctoral virology trainees working in their labs. Predoctoral training leading to the Ph.D. degree involves formal course work in microbiology and/or immunology, as well as other areas of biology, research rotations, teaching, and the qualifying exam in the first three semesters, with dissertation research beginning in year one and becoming the primary focus of activity after completion of the qualifying exam. Intensive training in the methods, logic, and responsible conduct of research are supplemented with a wide array of opportunities for scientific interactions. The median time to obtain the Ph.D. degree is 5.7 years. Yale Graduate and Medical Schools, and Virology trainers make extensive efforts to attract and retain trainees from diverse backgrounds, particularly under-represented minority groups. This application requests funding to continue support for four predoctoral trainees in each year. Trainees will supported by this grant for a maximum of two years.