Developmental Research Program

摘要： 多发性骨髓瘤马约诊所SPORE的发展研究项目的目标是 支持创新，科学合理的项目，调查任何领域有关的翻译 骨髓瘤研究。该计划的资金将刺激发展研究， 这些技术和理论方法以前可能没有用于骨髓瘤研究。在 这样做提供了一种机制，通过这种机制，孢子可以增加科学家和临床医生的数量， 致力于骨髓瘤转化研究的研究者。开发研究 该计划将鼓励开发合适的项目，协调项目审查和选择， 向执行委员会提出拨款建议，并监察研究进度。我们有 要求每年130，000美元（每年80，000美元来自SPORE基金，每年增加50，000美元， 匹配资金从马约诊所癌症中心）的发展研究计划。我们的目标是 每年为两至三个项目提供研究支持，为期一年，第二年提供支持 这是可能的，因为在实现项目既定目标方面取得了特殊进展。长期目标是 将发展项目产生的结果转化为发病率和死亡率的降低 骨髓瘤的发病率。如果没有SPORE项目的资金、基础设施和专业知识， 调查人员认为，我们设想的那种创新发展研究项目不太可能实现 必有结果。具体而言，发展研究计划的主要目标是：（1） 鼓励创新的转化研究，这是有前途的，并有可能改善结果， 骨髓瘤和成熟到独立资助的项目;（2）促进基础之间的广泛合作 骨髓瘤转化研究中的科学和临床学科 （3）鼓励研究者将他们在其他肿瘤类型中的研究成果应用于翻译 骨髓瘤的研究;（4）产生新的假设，可以测试，并提供基础， 未来的大规模研究项目或临床试验，以降低骨髓瘤的发病率和死亡率 rates.

ABSTRACT: The goal of the Developmental Research Program in the Mayo Clinic SPORE in Multiple Myeloma is to support innovative, scientifically sound projects that investigate any area pertaining to translational myeloma research. Funding from this program will stimulate developmental research that incorporates techniques and theoretical approaches that may not have been previously utilized in myeloma research. In so doing it provides a mechanism by which the SPORE can increase the number of scientists and clinical investigators who are committed to translational myeloma research. The Developmental Research Program will encourage the development of suitable projects, coordinate project review and selection, make funding recommendations to the Executive Committee, and monitor research progress. We have requested $130,000 annually ($80,000 per year from the SPORE funds augmented by $50,000 per year in matching funds from the Mayo Clinic Cancer Center) for the Developmental Research Program. We aim to provide research support to two to three projects per year for one year with a second year of support possible based on exceptional progress towards the stated aims of the project. The long term goal is to translate the findings generated by developmental projects into a reduction in the incidence and mortality rates of myeloma. Without the funding, infrastructure, and expertise of the SPORE projects and investigators, it will be unlikely that innovative developmental research projects of the kind we envision can be brought to fruition. Specifically, the primary goals of the Developmental Research Program are to: (1) encourage innovative translational studies that are promising and have the potential to improve outcome in myeloma and mature into independently funded projects; (2) foster extensive collaboration between basic science and clinical disciplines in translational research in myeloma in the context of the myeloma SPORE program; (3) encourage investigators to apply their research findings in other tumor types to translational research in myeloma and; (4)generate new hypotheses that can be tested and provide the foundation for future large-scale research projects or clinical trials in order to reduce myeloma incidence and mortality rates.