Improved Prenatal Genetic Screening Decision Making through Interactive Technology

 描述（由申请人提供）：本申请的目的是：1）开发产前筛查游戏应用原型（PS-GAP）; 2）对PS-GAP进行初步评估，评估孕妇及其伴侣对产前基因筛查的知识、满意度和决策冲突。具体目标1：为孕妇及其伴侣创建一个游戏工具，用于提高知识和评估有关产前基因筛查的个人价值。 研究方法：与游戏专家和临床专家合作开发原型，利用医疗保健领域的初步研究和相关工作。然后，将与各利益攸关方团体反复修订原型。具体目标二：评估游戏原型对孕妇及其伴侣产前基因筛检知识、使用者满意度及决策冲突的影响。 方法：通过启发式评估和用户测试确定可用性和可接受性。孕妇和伴侣将独立参与PS-GAP，然后比较他们的选择。所有参与者将完成衡量知识、满意度和决策冲突的事后调查。将随机选择一个小组，对他们的经历进行深入采访。未来研究：这R21将证明可行性的发展和初步效用的游戏工具的知识和决策冲突有关的产前遗传筛查。未来的研究将是一个多站点的 随机对照试验，以测试这种方法对相关结果的有效性，包括知识，痛苦和决策满意度。潜在影响：由于专注于改善患者决策和参与，这种类型的工具具有广泛的应用。例如，它可以在整个怀孕过程中增加其他临床相关材料，并在其他充满价值的基因检测环境中可能有用。研究团队：我们的团队是唯一有资格实现本研究目标的团队。此应用程序包括与犹他州的娱乐艺术与工程计划，在美国的游戏开发的顶级程序之一，和P20美国国立卫生研究院犹他州中心的道德，法律的和社会研究的卓越合作，重点是人口筛查产前筛查和新生儿筛查妇女和儿童的健康护理。

 DESCRIPTION (provided by applicant): The purpose of this application is to 1) develop a prenatal screening gaming application prototype (PS-GAP) and 2) conduct a preliminary assessment of the PS-GAP on knowledge, satisfaction, and decisional conflict about prenatal genetic screening for pregnant women and their partners. Specific Aim 1: Create a gaming tool for pregnant women and their partners to use to improve knowledge and to assess personal values about prenatal genetic screening. Methods: Develop a prototype in collaboration with gaming experts and clinical experts, leveraging preliminary studies and related work in the healthcare field. The prototype will then be revised in an iterative process with various stakeholder groups. Specific Aim 2: Assess the gaming prototype on knowledge, user satisfaction and decisional conflict about prenatal genetic screening among pregnant women and their partners. Methods: Determine usability and acceptability through both heuristic evaluation and user testing. Pregnant women and the partners will independently engage with the PS-GAP and then compare their choices. All participants will complete post-surveys measuring knowledge, satisfaction and decisional conflict. A sub group will be randomly selected for in-depth interviews about their experiences. Future Research: This R21 will demonstrate feasibility of the development and preliminary utility of a gaming tool on knowledge and decisional conflict related to prenatal genetic screening. Future research will be a multi-site randomized control trial to test the effectiveness of this approach on relevant outcomes including knowledge, distress, and satisfaction with decision-making. Potential Impact: Because of its focus on improved patient decision-making and engagement, this type of tool has widespread application. For example, it can augment other clinically relevant materials throughout pregnancy and be potentially useful in other value-laden genetic testing environments. Research Team: Our team is uniquely qualified to achieve the aims of this study. This application includes collaboration with the University of Utah's Entertainment Arts and Engineering program, one of the top programs in the U.S for game development, and the P20 NIH Utah Center for Excellence in Ethical, Legal and Social Research focused on population screening in prenatal screening and newborn screening in women's and children's health care.