K24 Clinical research in Antimicrobial Resistance and Hospital Epidemiology

描述(由申请人提供)：目前的方案是对以前资助的K24进行竞争性续签。首席调查员安东尼·哈里斯博士是传染病内科医生和流行病学家。在他十四年的教职生涯中，他发表了125多篇手稿。在这些手稿中，他有50多篇是第一作者或最后作者。这些论文大多集中在以下研究领域：抗菌药物耐药性、医院流行病学、感染控制以及抗菌药物耐药性研究的流行病学和统计学方法。从他指导到现在，他的学员已经出版了450多本出版物。已有101种出版物成为辅导者/导师出版物。33名学员中有18名目前正在从事学术医疗事业。在他的K24的最初五年里，他成功地完成了所有提出的目标，并指导了六名教师的职业发展奖。在K24期间，他有超过46份出版物，其中44份涉及学员。他目前的资助水平包括一份NIH R01，一份AHRQ R01，一份经常要求额外分包合同的疾控中心合同，一名NIH合同的联合调查员和两项行业赞助的研究拨款。K24的更新对于他继续指导抗生素耐药性、医疗保健相关感染和医院流行病学等新兴领域的年轻研究人员并继续发展他的研究的愿望至关重要。他将选修额外的课程，以帮助将他的研究转移到集群随机试验、基因组流行病学、比较有效性研究以及微生物组和抗生素耐药性研究等领域。受保护的时间对哈里斯博士实现这些目标至关重要；如果没有K24续签，他将不得不参加更多关于传染病服务的工作，并进行更多的医院流行病学和质量改进，以增加针对他工资的报销。

DESCRIPTION (provided by applicant): The current proposal is a competitive renewal of a previously funded K24. The Principal Investigator, Dr. Anthony Harris, is an infectious disease physician and epidemiologist. During his fourteen years as faculty, he has had more than 125 manuscripts published. Among these manuscripts, he has been first or last author on more than 50. Most of these manuscripts have been focused in the following research areas: antimicrobial resistance, hospital epidemiology, infection control, and epidemiological and statistical methods in the study of antimicrobial resistance. His mentees have had over 450 publications from the time of his mentoring to the present. 101 publications have been mentee/mentor publications. Eighteen of 33 mentees are presently pursuing academic medical careers. In the initial five years of his K24, he successfully completed all proposed aims and mentored six faculty's career development awards. During the K24 period, he had over 46 publications of which 44 involved mentees. His current level of funding includes an NIH R01, an AHRQ R01, a CDC contract that has frequent requests for additional sub-contracts, a co-investigator on an NIH contract and two industry-sponsored research grants. Renewal of this K24 is critical to his desire to continue to mentor young investigators in the emerging areas of antibiotic-resistance, healthcare-associated infections and hospital epidemiology and to continue to evolve his research. He will take additional coursework to help move his research into the areas of cluster-randomized trials, genomic epidemiology, comparative effectiveness research and the study of the microbiome and antibiotic-resistance. The protected time is critical to Dr. Harris achieving these goals; without the K24 renewal, he will have to attend more on the infectious disease service and perform more hospital epidemiology and quality improvement in order to increase reimbursement directed towards his salary.