Cardiac MR and CT Research

 描述(由申请人提供)：我们寻求继续支持我们的NIH培训补助金T32 HL076136-10，名为“心脏MR CT研究”，基于马萨诸塞州综合医院(MGH)心脏MR PET CT计划，这是一个放射学/心脏病学联合计划。此次续签申请是基于该计划在前10年非常成功的记录，记录如下：1)该计划的受训人员对国家生物医学、行为和临床研究议程的影响-69%的前受训人员是学术机构的教员，75%的受训人员在地区、国家或国际领导职位上担任 63%的受训者已获得独立资金以继续他们的研究；以及2)培训多元化(11/27(42%)的项目受训人员是代表不足的少数族裔)和训练有素的劳动力(20名医学博士、4名医学博士、3名博士)。这一续订申请提供了一项深入的培训计划，其中包括工程/物理、基础和翻译研究、早期临床成像研究和试验以及心脏成像领域的临床试验/流行病学/结果等职业轨迹中的教学正式和基于项目的个人培训元素。该计划得到了30名资金雄厚的教职员工的支持(该计划第一年(2014)的资金为64,194,470美元；获得了R01奖学金的52人，PPG/U01计划的26人)，其中21/30人已经获得了独立资金，直到本申请的第三年(2016))，他们拥有代表10个项目和部门的经验和长期致力于指导的记录。该学院结合了七个重点领域的杰出专业知识(计算机断层扫描、磁共振成像、其他非侵入性成像，如PET和超声心动图、侵入性成像(IVUS、OCT)、生物标志物/遗传学/代谢组学、成本效益和统计学)。重要的是，几个正在进行和资助的大型未来试验(PROMISE、ROMICAT II、RESPEVE)为MD调查人员提供了出色的培训和研究机会，同时在MR和生物标记物领域开展了重要的基础和翻译科学工作。该计划的行政结构包括计划管理委员会、导师小组和外部咨询委员会，以保证对学员进行有效的指导和监督。2012年1月4日，医学硕士Udo Hoffmann成为培训计划的PI，他是一名专注于CT的高级临床试验人员。他与这份申请中列出的大多数教职员工都有密切的研究合作。霍夫曼博士将与副主任托马斯·G·内兰医学博士一起领导该项目，内兰博士是一名初级教员，免费提供基础/翻译MR科学方面的培训。这两个机构都将与一个项目管理委员会和一个外部咨询委员会密切合作。K24奖支持霍夫曼博士的努力，他还为尼兰博士和赠款的管理提供了额外的部门支持。详细的培训计划和明确的职责确保了项目的凝聚力，并促进了多学科研究合作。现在需要资金为第三个5年资金周期续签计划。

 DESCRIPTION (provided by applicant): We seek continued support for our NIH Training Grant T32 HL076136-10 entitled "Cardiac MR CT Research" based in the Massachusetts General Hospital (MGH) Cardiac MR PET CT program, a joint Radiology/Cardiology program. This renewal application is based on the highly successful track record of this program over the first 10 years, documented by 1) the impact trainees of this program had on the Nation's biomedical, behavioral and clinical research agenda - 69% of former trainees are faculty at academic institutions, 75% serve in regional, national or international leadership positions with a teaching, research, or clinical focus, and 63% have acquired independent funding to continue their research; and 2) training a diverse (11/27 (42%) of all program trainees were underrepresented minority) and highly trained workforce (20 MD; 4 MD PhD; 3 PhD). This renewal application provides an in depth training plan with didactic formal and project based individual training elements across career tracks of Engineering /Physics, Basic and Translational Research, Early Clinical Imaging Research and Trials, and Clinical Trials/Epidemiology/Outcomes in cardiac imaging. The program is supported by 30 well funded faculty members ($64,194,470 of funding for year 1 (2014) of the program; 52 awarded R01 grants and 26 PPG/U01 programs) and 21/30 have already secured independent funding until year 3 (2016) of this application) with experience and a long track record of commitment to mentoring representing ten programs and departments. This faculty combines outstanding expertise in seven focus areas (Computed Tomography, Magnetic Resonance Imaging, other noninvasive Imaging such as PET and Echocardiography, Invasive Imaging (IVUS, OCT), Biomarkers/Genetics/Metabolomics, Cost Effectiveness, and Statistics). Importantly, several large ongoing and funded future trials (PROMISE, ROMICAT II, REPRIEVE) provide outstanding training and research opportunities for MD investigators, while significant basic and translational science work is performed in MR and biomarker areas. The program's administrative structure includes a Program Management Committee, Mentor groups and an External Advisory Board to guarantee an efficient mentoring and supervision of trainees. On 04/01/2012, Udo Hoffmann, MD MPH, a senior clinical trialist with focus on CT, became the PI of the Training Program. He has close research collaborations with the majority of the faculty listed in this application. Dr. Hoffmann, will lead the program together with the Associate Director Tomas G. Neilan, MD, a junior faculty with a complimentary basic/translational MR science focus. Both will closely work with a Program Management Committee and an External Advisory Board. A K24 award supports Dr. Hoffmann's effort and he has additional departmental support for Dr. Neilan and for the administration of the grant. Detailed training plans and clear responsibilities ensure program cohesiveness and foster multidisciplinary research collaboration. Funds are now requested to renew Program for a third 5 year funding cycle.