Cell Signaling of Host Defense

由迈克尔·B·费斯勒医学博士领导的国家环境健康科学研究所内壁研究部呼吸生物学实验室的宿主防御小组自成立以来已进入第十个年头。自上次年度报告以来出版的出版物包括： 1.一位资深作者报道，microrna-33通过改变质膜脂筏微区中的胆固醇水平来调节巨噬细胞炎症信号的强度(Pubmed Id 27471270)。 2.一份合作报告显示，microrna-33在碳纳米管引起的肺部疾病中也发挥作用，并可能在肺部疾病结节病中发挥作用(Pubmed Id 26641802)。 3.有报道称，接受hmg辅酶A还原酶抑制剂瑞舒伐他汀治疗的人类志愿者的高密度脂蛋白中的蛋白质谱发生了变化；这可能需要增强高密度脂蛋白相关蛋白的抗炎功能(Pubmed Id 26483418)。 4.一篇关于脂质在肺部感染和炎症中的作用的特邀评论文章(Pubmed ID 27286794) 5.一篇关于表面活性物质脂质在炎症和感染性肺部疾病中的作用的特邀评论文章(Pubmed ID 26859434) 6.一篇关于胆固醇合成途径对宿主防御的影响的特邀评论文章(Pubmed ID 26758950) 7.一篇关于胆固醇代谢在控制适应性免疫反应中的作用的特邀评论文章(Pubmed ID 26149587) 8.对《Am J Respir Crit Care Med》发表的一份报告的特邀社论评论，该报告描述了血清脂蛋白与哮喘之间的新关系(Pubmed ID 25932757) 自上次报告以来，我们还取得了其他成就，包括Fessler博士在密歇根州汉密尔顿落基山实验室的特邀演讲；杜克大学先天免疫研讨会(主讲人)；维克森林大学微生物学和免疫学系；国立犹太医院肺科；NIH免疫兴趣小组研讨会系列；以及在国家犹太医院的蛋白质组学和代谢组学研讨会上。此外，费斯勒博士还在2016年美国胸科学会国际会议上主持了一场关于肺部炎症的科学研讨会。费斯勒博士的实习生也获得了旅游和抽象类奖项的认可。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its tenth year at the NIEHS since inception. Publications since the last annual report include: 1. a senior author report that microRNA-33 regulates the strength of inflammatory signaling by macrophages by changing cholesterol levels in lipid raft microdomains of the plasma membrane (Pubmed ID 27471270) 2. a collaborative report showing that microRNA-33 also plays a role in lung disease caused by carbon nanotubes and may play a role in the lung disease sarcoidosis (Pubmed ID 26641802) 3. a report that human volunteers treated with rosuvastatin, an HMG CoA reductase inhibitor, have a changed profile of proteins in their high density lipoproteins; this may need to enhanced anti-inflammatory function of the HDL-associated proteins (Pubmed ID 26483418) 4. an invited review article on the role of lipids in pulmonary infections and inflammation (Pubmed ID 27286794) 5. an invited review article on the role of surfactant lipids in inflammatory and infectious lung diseases (Pubmed ID 26859434) 6. an invited review article on effects of the cholesterol synthesis pathway on host defense (Pubmed ID 26758950) 7. an invited review article on the role of cholesterol metabolism in controlling adaptive immune responses (Pubmed ID 26149587) 8. an invited editorial commentary on a published report in Am J Respir Crit Care Med that describes novel relationships between serum lipoproteins and asthma (Pubmed ID 25932757) Additional accomplishments since our last report include invited talks presented by Dr. Fessler at Rocky Mountain Laboratories in Hamilton, MT; the Duke University Innate Immunity Symposium (keynote speaker); the Department of Microbiology and Immunology of Wake Forest University; the Pulmonary Division of National Jewish Hospital; the NIH Immunology Interest Group Seminar Series; and at a Proteomics & Metabolomics Workshop at National Jewish Hospital. In addition, Dr. Fessler chaired a scientific symposium on lung inflammation at the 2016 American Thoracic Society International Conference. Dr. Fesslers trainees were also recognized through travel and abstract awards.