Pacing across the membrane: Characterising the PACE family of multidrug efflux systems

世界卫生组织承认细菌抗微生物药物耐药性是全球人类健康的主要威胁之一。多药外排泵是一类重要的耐药蛋白，它们位于细菌细胞膜上，将抗菌素移出细胞。我们最近发现了15年来第一个新的多药物外排泵家族。我们的项目将定义该家族的精确抵抗功能，并确定阻断其功能的方法。

The World Health Organisation recognises bacterial antimicrobial resistance as one of the major threats to human health worldwide. Multidrug efflux pumps are an important class of resistance proteins that sit in the bacterial cell membrane and move antimicrobials out of the cell. We recently discovered the first new family of multidrug efflux pumps to be described in 15 years. Our project will define the precise resistance functions of this family and identify ways to block their function.