Tennessee Center for AIDS Research (TN-CFAR)

 描述（由申请人提供）：数十年的研究已经产生了理论上可以预防所有新的艾滋病毒感染并最终消除艾滋病的知识和工具。现实福尔斯远远不够，部分原因是主要的迫切需求没有得到满足，其中许多属于两个领域：“连续护理”（确保所有艾滋病毒感染者得到诊断、与护理联系并继续接受护理）;和“个性化艾滋病毒护理”（确保在了解个体间差异决定因素的基础上进行最安全和有效的治疗）。拟议中的田纳西州艾滋病研究中心（TN-CFAR）位于美国东南部，该地区新感染艾滋病毒的人数最多，艾滋病毒感染者最多。在Simon Mallal教授（被招募到范德比尔特领导该中心）的领导下，我们在一个研究密集型机构（范德比尔特大学，VU），一个专注于少数民族和服务不足人群的学术健康科学中心（Meharry医学院，MMC）和一个学术参与的州卫生部门（田纳西州卫生部，TDH）之间建立了独特的合作伙伴关系。我们的愿景是产生变革性的，本地和全球的翻译影响。在这一愿景的指导下，我们的使命是协调机构和社区资源，集中努力实现高度优先目标，以最有效地减轻艾滋病毒/艾滋病的负担，并在国家和全球推广这些惠益。我们将利用VU，MMC和TDH的互补优势，将研究工作集中在未满足的需求上。这一战略也将最有效地服务于传统的CFAR角色，即机构领导、核心服务和促进初级调查员的职业发展。我们将专注于四个具体目标：1）促进VU，MMC和TDH之间的合作，集中资源和研究，以改善田纳西州及其他地区的护理连续性; 2）协调研究应对艾滋病毒干预措施的个体间变异的决定因素，以改善个性化的艾滋病毒护理，结果和资源利用; 3）在MMC以及MMC和VU之间为艾滋病毒临床/转化研究创造新的机会并采取行动;和4）开发和发展以艾滋病毒为重点的社区参与研究的新重点，这将贯穿于本CFAR。

 DESCRIPTION (provided by applicant): Decades of research have generated knowledge and tools that, in theory, could prevent all new HIV infections and ultimately eliminate AIDS. Reality falls far short, in part due to major pressing unmet needs, many of which fall within two domains: "Continuum of Care" (assuring that all HIV-infected individuals are diagnosed, connected to care, and maintained in care); and "Personalized HIV Care" (assuring optimally safe and effective therapy based on understanding determinants of inter-individual variability). The proposed Tennessee Center for AIDS Research (TN-CFAR) is located in the Southeastern US, the region with the greatest number of new HIV infections, and of persons living with HIV. Under the leadership of Prof. Simon Mallal (recruited to Vanderbilt to lead this Center) we have forged a unique partnership between a research- intensive institution (Vanderbilt University, VU), an academic health sciences center focused on minority and underserved populations (Meharry Medical College, MMC), and an academically engaged state health department (Tennessee Department of Health, TDH). Our vision is to have transformative, local and global translational impact. Guided by this vision, our mission is to coordinate institutional and community resources and focus efforts on high-priority targets to most effectively reduce the burden of HIV/AIDS and generalize these benefits nationally and globally. We will leverage complementary strengths of VU, MMC, and TDH to focus research efforts on unmet needs. This strategy we will also most effectively serve the traditional CFAR roles of institutional leadership, core service, and fosterig career development of junior investigators. We will focus on four specific aims: 1) To foster collaborations between VU, MMC, and TDH that focus resources and research to improve the continuum of care in Tennessee and beyond; 2) To coordinate research into determinants of interindividual variability in response to HIV interventions so as to improve personalized HIV care, outcomes, and resource utilization; 3) To create and act upon new opportunities for HIV clinical/translational research at MMC, and between MMC and VU; and 4) To develop and grow a new emphasis on HIV-focused community engaged research that will pervade this CFAR.