Pilot/Exploratory Studies Core (PESC)

项目摘要/摘要-试点和探索性研究核心(PESC) 杜克OAIC的飞行员/探索性研究核心(PESC)的目标是进行高质量的飞行员 在我们的项目中，为选择、设计和进行后续更大的假设驱动研究提供信息的项目 主题：认识和优化储备和韧性。具体目标是：1)提升一流质量 与晚年储备和韧性相关的科学，2)吸引和培养早期优秀的多样化干部 老龄化研究中的研究人员或寻求与我们的 主题，以及3)与关键利益相关者建立和保持关系，以最大限度地提高影响和翻译 通过这个和未来的OAIC开展的工作。通过利用机构资金，我们将在 每年至少三个试点项目。我们使用小额试行资金作为快速反应机制 利用尖端领域的优势。PESC从世界各地征集和挑选高质量的先导研究 杜克大学医学中心使用内部和外部相结合的严格、多阶段流程 复习一下。委员会密切监察研究进展，并协助制订更大的拨款建议。 来自先导研究的结果。为了实现我们的目标，Duke PESC包括几个高度创新的功能： 1)试点赠款研讨会，由OAIC主任Kenneth Schmader开发，并在#年经常要求 国家场地，2)将患者/社区代表纳入审查小组，挑选飞行员，3) 数据集成工作组，这是科学发展、监督和促进的中心枢纽 翻译，以及4)支持无资金支持的先导研究申请者的科学和职业的机制。四 试点计划在头两年提出。环境食物局局长调查一项预先计划的可行性和成效 手术运动干预(“康复训练”)以提高择期手术老年人的韧性 做手术。PES2研究了瞬时受体电位香草素4(TRPV4)介导的机制。 转导在恢复陈旧软骨细胞储备能力中的作用，潜在地提高其修复能力 能承受生理负荷，避免骨关节炎。PES3将演示老化对自噬的影响 并寻找特定的机制靶点来增强肌肉储备和减少 石棺减少症。PES4结合了临床和生物学数据，以开发适用于 预测接受化疗的老年多发性骨髓瘤患者的复原力。PESC对公众的影响 健康通过开展研究来开发知识，以保持或恢复美国老年人的独立性， 通过在面对慢性和急性压力时提高储备和韧性。

PROJECT SUMMARY/ABSTRACT – Pilot and Exploratory Studies Core (PESC) The objective of the Pilot/Exploratory Studies Core (PESC) of the Duke OAIC is to conduct high quality Pilot Projects that inform the selection, design, and conduct of subsequent larger, hypothesis-driven research in our theme: to understand and optimize reserve and resilience. The Specific Aims are to: 1) advance top quality science related to late-life reserve and resilience, 2) attract and nurture a diverse cadre of outstanding early investigators in aging research or established investigators pursuing promising new directions related to our theme, and 3) build and sustain relationships with critical stakeholders to maximize the impact and translation of the work conducted through this and future OAICs. By leveraging institutional funding, we will support at least three Pilot Projects per year. We use small exploratory pilot monies as a rapid response mechanism to take advantage of cutting edge areas. The PESC solicits and selects high quality pilot studies from across Duke University Medical Center using a rigorous, multi-stage process that incorporates internal and external review. The PESC carefully monitors study progress and assists in the development of larger grant proposals from pilot study findings. To accomplish our Aims, the Duke PESC includes several highly innovative features: 1) the Pilot Grants Workshop, developed by OAIC Director Kenneth Schmader and frequently requested in national venues, 2) the inclusion of patient/community representatives on the Review Panel selecting pilots, 3) the Data Integration Working Group, which is a central hub for scientific development, oversight, and promoting translation, and 4) mechanisms that support the science and careers of unfunded pilot study applicants. Four Pilot Projects are proposed in the first two years. PES1 investigates the feasibility and efficacy of a pre- operative exercise intervention (“prehabilitation”) to enhance resilience for older adults undergoing elective surgery. PES2 investigates the role of transient receptor potential vanilloid 4 (TRPV4)-mediated mechano- transduction in restoring the reserve capacity of old chondrocytes, potentially improving their ability to withstand physiological load and avoid osteoarthritis. PES3 will demonstrate the effect of aging on autophagy in muscle stem cells and seek specific mechanistic targets for enhancing muscle reserve and reducing sarcopenia. PES4 incorporates clinical and biological data to develop clinical prediction rules useful in predicting resilience in older multiple myeloma patients undergoing chemotherapy. The PESC impacts public health by performing studies that develop knowledge to maintain or recover independence in older Americans, by promoting reserve and resilience in the face of chronic and acute stressors.