发作性睡病及相关疾病中心 (P50)-猫眼课题宝

发作性睡病及相关疾病中心 (P50)

批准号：

9245340

负责人：

Emmanuel J Mignot

金额：

$7.82万

依托单位：

STANFORD UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2016

资助国家：

美国

项目状态：

已结题

起止时间：

2016-04-01 至 2017-01-31

来源：

https://reporter.nih.gov/project-details/9245340

关键词：

Affect Agonist Alleles American Animal Model Antibodies Antigens Area Autoantibodies Autoimmune Diseases Autoimmune Process B-Lymphocytes Basic Science Blood - brain barrier anatomy Blood specimen Brain CD4 Positive T Lymphocytes California Canis familiaris Case-Control Studies Cataplexy Cells Cellular Immunity Chemotaxis Chronic Complement County DNA DNA Sequence Data Development Diagnosis Diagnostic tests Diffuse Disease Environmental Health Environmental Risk Factor Epidemiological Factors Epitopes Event Excessive Daytime Sleepiness Extramural Activities Family member Frequencies Fruit Functional disorder Funding Future Genetic Genetic Polymorphism Genetic Programming Genomic DNA Genomic Segment Genotype Goals Grant HLA-DQB1 Human Immune Immune system Immunology Incidence Individual Industry Insulin-Dependent Diabetes Mellitus Intervention Interview Investigation Investments Islets of Langerhans Transplantation Knowledge Lead Matched Group Measures Medical Records Methods Modeling Mutation Narcolepsy National Institute of Neurological Disorders and Stroke Neurons North America Onset of illness Pathogenesis Pathway interactions Patients Pattern Peptides Peripheral Blood Mononuclear Cell Positioning Attribute Predisposition Prevalence Preventive measure Process Proteins REM Sleep Reaction Research Research Project Grants Resources Risk Risk Factors Sample Size Serum Sleep Disorders Source Stem cell transplant Streptococcus Susceptibility Gene Symptoms T-Lymphocyte TCR Activation TNFRSF5 gene TRA@ gene cluster Testing Therapeutic Studies Time Translating United States National Institutes of Health Universities Ursidae Family Variant Washington Work base clinical risk cohort effective therapy follow-up genetic association genetic variant genome wide association study hypocretin improved interest multidisciplinary nervous system disorder neurochemistry new therapeutic target novel novel diagnostics novel therapeutics population based prevent programs public health relevance rare variant receptor transplantation typing

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中文摘要

翻译

描述(由申请人提供)：发作性睡病-猝倒是一种严重的慢性睡眠障碍，导致白天过度嗜睡和猝倒。它是最常见的神经疾病之一，在北美大约每2000人中就有1人受到影响。这个多学科项目关注于人类发作性睡病的研究，并试图确定引发发作性睡病的遗传和环境因素。我们还想了解为什么免疫系统会破坏发作性睡病中的下丘脑神经元，并对其进行预防/治疗。

英文摘要

DESCRIPTION (provided by applicant): Narcolepsy-cataplexy is a serious and chronic sleep disorder resulting in excessive daytime sleepiness and cataplexy. It is one of the most common neurological disorders, affecting approximately 1 in 2,000 individuals in North America. This multidisciplinary project focuses on the study of human narcolepsy and seeks to identify the genetic and environmental factors involved in triggering narcolepsy. We also want to understand why the immune system destroys hypocretin neurons in narcolepsy and to prevent/cure it.

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