Translational Research in Lung Biology and Disease

在美国，肺部疾病是导致发病率和死亡率的重要原因。虽然所有其他主要死亡原因都在减少，但经年龄调整后的肺部疾病死亡率继续上升。Cobre第三阶段续签申请的总体目的是继续发展佛蒙特大学医学院佛蒙特州肺脏中心(VLC)的肺生物学和疾病研究计划。VLC项目的核心是卓越。科学优势包括呼吸道上皮细胞生物学、囊性纤维化、哮喘炎症、肺生理学、转译动物研究以及肺部疾病发病机制的临床研究。在上一个供资周期中，我们继续积累了生产力的记录，包括：招聘了大量训练有素的博士和医学博士和肺科科学家，发表了影响很大的同行评议出版物，并继续增加了外部资金。 佛蒙特州肺科中心要继续取得成功，一个关键的条件是要有一个刺激的环境，在这个环境中可以实现最佳的职业发展。因此，VLC-Cobre目前的目标是： 1)发展一批有才华的医学博士和博士生物医学研究人员的职业生涯 2)就具有竞争力的科学方法提供熟练的指导和咨询 3)保持尖端的研究环境 4)开发临床研究核心，保持转基因/基因敲除动物和小动物表型核心， 这一拟议的计划将通过形成与哪个中心的联系来实现VLC的可持续性 将创建授予申请。这项提案还解决了扩大和支持 UVM的翻译性多学科研究，因为这是基础分子、细胞 基因科学被转化为新的诊断和治疗方法。

Lung disease is a significant cause of morbidity and mortality in the United States. While all other major causes of death are decreasing, age-adjusted mortality due to lung disease continues to rise. The overall purpose of this COBRE Phase III renewal application is to continue the development of the research program in Lung Biology and Disease at The Vermont Lung Center (VLC) of the University of Vermont College of Medicine. The keystone of the VLC program is excellence. The scientific strengths include airway epithelial cell biology, cystic fibrosis, asthma inflammation, lung physiology, translational animal studies, and clinical investigation into the pathogenesis of lung disease. In the last funding cycle we have continued to amass a record of productivity including: recruitment of a critical mass of well trained PhD and MD pulmonary scientists, high-impact peer-reviewed publications and continued as well as considerable increase in extramural funding. A critical requirement for the continued success of the Vermont Lung Center is the stimulating environment in which optimal career development can occur. The current goals of the VLC-COBRE are therefore to: 1) Develop the careers of a group of talented MD and PhD biomedical investigators 2) Provide skilled mentoring and consultation on com petitive scientific approaches 3) Maintain a "cutting edge" research milieu 4) Develop a clinical studies core, maintain transgenic/knockout animal and small animal phenotyping core, This proposed program will build towards sustainability of the VLC by forming the nexus from which center grant applications will be created. This proposal also addresses the urgent need to expand and support translational multidisciplinary research at UVM, because this is how advances in basic molecular, cellular and genetic science are converted into new methods of diagnosis and therapy.