Asymmetric Synthesis of Biologically Active Marine Natural Products

研究天然产物的合成为发现新的 化学和生物方向。我们研究计划的首要目标是研究 具有药用价值的小分子化学合成及化学进展 用于下一代药物合成的技术。通过这个项目，我们将更好地 了解自然界如何进行环加成类型的二聚反应以产生更高的 吡咯-咪唑生物碱的订购。我们将测试生物合成假说并开发 这些天然产物的仿生合成方法。受氧化剂的启发 金属酶，我们将进一步开发C-H和烯烃氧化的新催化剂体系。我们 还将研究环二核苷酸如何介导先天免疫反应。我们的研究将会有 对小分子药物的发现和生产产生直接影响。

Studying the synthesis of natural products provides rich opportunities for identifying new directions in chemistry and biology. The overarching goal of our research program is to study the chemical synthesis of small molecules of medicinal relevance and to advance chemical technology for the next-generation of drug synthesis. Through this project, we will better understand how nature performs cycloaddition-type dimerization reactions to produce higher order pyrrole-imidazole alkaloids. We will test the biosynthetic hypotheses and develop biomimetic synthetic approaches to these natural products. Inspired by the oxidative metalloenzymes, we will further develop new catalyst systems for C-H and olefin oxidation. We will also study how cyclic dinucleotides mediate innate immune response. Our research will have direct impacts on the discovery and manufacturing of small-molecule drugs.