Core F: Research Education Component (RL5)

研究教育组成部分核心(核心F)--项目摘要 研究教育部分(REC)的核心将监督 针对早期研究人员的培训计划，将重点放在弥合临床前和 预防、减缓和治疗阿尔茨海默病(AD)的治疗干预的临床进展。我们会 利用丰富的现有机构资源，包括克劳德·D·佩珀老年美国人独立 中心、我们的临床和翻译科学研究所(CTSI)和维克森林创新公司(与 行业)提供坚实的多学科基础设施，以支持侧重于 翻译阿尔茨海默病神经科学研究，特别是关于代谢和 血管危险因素与疾病。我们将从维克森林的广泛科学社区中提取出 导师，并将从不同种族和民族招募早期调查人员和其他受训人员 通过多个维克森林中心(例如ADCC、Sticht老龄中心、Maya Angelou)提供的背景 健康公平中心，高血压和血管研究中心，比较医学/灵长类 中心)，并通过附近的附属学术机构，包括两所历史悠久的黑人学院和 与我们建立了合作关系的大学(HBCU)。REC核心将 为初级教员实施为期18个月的创新强化培训计划，包括新的 翻译研究经验和有针对性的指导，以促进从研究孤岛向 高度协作和跨学科的科学。REC还将提供多个其他培训 所有职业发展水平的调查人员的机会都集中在从正常状态的早期过渡 使用几个平台(例如，座谈会， 研讨会、讲习班、案例会议、期刊俱乐部)。这些和其他REC核心倡议将是 具体目标如下：1)扩大有前途的初级调查员的职业重点 教师通过新的多学科翻译科学地图计划，将提供个性化 以及有针对性的指导、培训和新的研究经验，以支持联合开发 基础科学和临床研究能力，重点是翻译神经科学；2)支持 研究AD或相关主题的初级调查人员的研究职业发展通过提供访问 多学科课程的结构化教学培训，其中也将重点发展策略 成功的国家学术和行业合作；3)吸引来自种族和少数民族的实习生 在AD研究中被严重低估的背景；以及4)评估和完善REC核心 使用既定的学术成功标准的课程。

Research Education Component Core (Core F) – Project Summary The Research Education Component (REC) Core will oversee the development and implementation of training programs for early-stage investigators that will focus on bridging the gap between preclinical and clinical development of therapeutic interventions to prevent, slow, and treat Alzheimer's disease (AD). We will leverage rich existing institutional resources, including the Claude D. Pepper Older Americans Independence Center, our Clinical and Translational Science Institute (CTSI), and Wake Forest Innovations (liaison with industry) to provide a solid, multi-disciplinary infrastructure to support a diverse training curriculum focused on translational AD neuroscience research, particularly with regard to the contributory role of metabolic and vascular risk factors and disease. We will draw from Wake Forest's extensive scientific community to identify mentors, and will recruit early-stage investigators and other trainees from diverse racial and ethnic backgrounds through multiple Wake Forest Centers (e.g., ADCC, Sticht Center on Aging, Maya Angelou Center for Health Equity, Hypertension and Vascular Research Center, Comparative Medicine/Primate Center), and through nearby affiliate academic institutions, including two Historically Black College and Universities (HBCUs) with whom we have established collaborative relationships. The REC Core will implement an innovative 18-month intensive and tailored training program for junior faculty that includes new translational research experiences and targeted mentoring to facilitate transitions from research silos toward highly collaborative and interdisciplinary science. The REC will also provide multiple other training opportunities for investigators at all levels of career development focused on early transitions from normal aging to MCI, and from MCI to AD and other forms of dementia using several platforms (e.g., symposiums, seminars, workshops, case conferences, journal clubs). These and other REC Core initiatives will be addressed with the following Specific Aims: 1) to expand the career focus of promising junior investigators faculty through a new multi-disciplinary Translational Science Mapping Program that will provide individualized and targeted mentoring, training, and new research experiences to support the development of combined competence in basic science and clinical research, with a focus on translational neuroscience; 2) to support research career advancement of junior investigators studying AD or a related topic by providing access to a multi-disciplinary curriculum of structured didactic training, which will also focus on strategies to develop successful national academic and industry collaborations; 3) to engage trainees from racial and ethnic minority backgrounds who are severely underrepresented in AD research; and 4) to evaluate and refine REC Core programs using established metrics of academic success.