Discovery of Chemical Probes and Therapeutic Leads

在这篇文章中，开发化学探针和治疗线索的新方法将由 不同的科学家团队。这个Cobre v\/将为高通量筛选创建新的文库，提供新的 关于先天免疫反应和神经退行性疾病的观点，使新的筛查成为可能 技术，并推进了虚拟放映的最新技术。拟议中的科布雷将建立一个网络 通过五个子项目在整个密歇根大学校园内开展科学合作： 1.免疫刺激小分子文库的研制 2.用于高通量药物筛选的神经疾病体外模型 3.多种小分子文库制备的新方法 4.用于快速化学探针识别的电化学化学发光阵列和发射体 5.实现高通量虚拟筛选的预测承诺 拟议中的科布雷将在加州大学的科学家之间建立一个生物医学合作的区域网络 和内穆尔儿童癌症研究中心。在所有五个子项目的丰富协作中， UD研究人员将与NCI分子靶标实验室(MTL)的科学家广泛接触 和化学生物实验室(CBL)，互动包括NCI科学家的指导、交叉培训 NCI研究生的经验，以及跟进有希望的合作机制 发现。 凭借新的核心仪器和设施，科布雷将增加生物医学的基础设施 在密歇根大学进行研究。该中心的范围将通过招聘教师和种子进一步扩大。 赠款，并通过明确的机制，促进对最初的生物和化学后续行动 发现。Cobre还将建立一个指导网络，支持 助理教员，并让他们加速走向独立资助的道路。

In this COBRE, novel approaches to developing chemical probes and therapeutic leads \N\\\ be pursued by a diverse team of scientists. This COBRE v\/ill create new libraries for high-throughput screening, provide new perspectives on innate immune response and neurodegenerative disease, enable new screening technology, and advance the state of the art in virtual screening. The proposed COBRE will build a network of scientific collaboration throughout the UD campus through five subprojects: 1. Development of an Immunostimulatory Small Molecule Library 2. In vitro neural disease models for high throughput drug screening 3. New Synthetic Methods for Diverse Small Molecule Library Preparation 4. Electrochemical Chemiluminescent Arrays and Emitters for Rapid Chemical Probe Identification 5. Realizing the predictive promise of high throughput virtual screening The proposed COBRE will establish a regional network of biomedical collaboration between scientists at UD and the Nemours Center for Childhood Cancer Research. In a rich collaboration across all five subprojects, UD researchers will interface extensively with scientists from the NCI Molecular Targets Laboratory (MTL) and Chemical Biology Laboratories (CBL), with interactions that include mentorship by NCI scientists, cross-training experiences for graduate students at NCI, and collaborative mechanisms for follow-up on promising discoveries. With new core instrumentation and facilities, this COBRE will increase the infrastructure for biomedical research at UD. The scope of the center will be further expanded through faculty recruitment and seed grants, and via explicit mechanisms that will facilitate both biological and chemical follow-up on initial discoveries. This COBRE will also establish a mentoring network that will support the career development of assistant faculty, and place them on an accelerated path toward independent funding.