Vulnerability to Drug Use & HIV: Advancing Prevention for Rural African Americans

翻译和预防科学中心(CTAPS)于2009年获得资助，以向 通过基因环境调查为农村非裔美国青年开展预防项目 (G-E)毒品使用和艾滋病毒相关行为的相互作用。拟议的延续增加了 CTAPS的科学议程，以更好地解决影响毒品使用和艾滋病毒相关行为的种族差异 乡村非裔美国人。新的研究表明，暴露在慢性压力下会影响大脑的功能 从童年和青春期开始的炎症、神经内分泌和神经认知系统。这个 慢性应激的负面后果影响健康相关行为并预测慢性疾病 衰老。新出现的证据表明，这些过程也可能影响年轻人和年轻人的 药物滥用和艾滋病毒相关行为的发展。该中心将赞助新一代 研究(A)暴露于空气中的神经内分泌、炎症和神经认知途径 农村非裔美国青年和年轻人的压力造成了吸毒和艾滋病毒相关疾病的脆弱性 影响潜在脆弱性的行为、(B)延展性风险和保护过程 机制；以及(C)将调查结果转化为新的、完善的青年预防干预措施 一般的，特别是农村的非裔美国青年。CTAPS将通过以下方式实现这些科学目标 为三个支持核心(炎症/神经内分泌、神经认知、生物统计学)提供基础设施 这将丰富来自核心项目和试点项目以及试点核心的数据。CTAPS将促进 中心附属调查人员、支持核心总监和核心项目PI之间的沟通；监督 管理全中心的预算和业务；提供基础设施和行政支持 三个支持核心和一个试点核心。CTAPS将通过跨学科工作组系统促进进展 旨在促进跨学科协作并组织中心资源的分配和 将研究成果传播给多个利益相关者，包括研究人员、政策制定者、教育 组织和公众。

The Center for Translational and Prevention Science (CTAPS) was funded in 2009 to inform the development of prevention programs for rural African American youth through investigations of gene-environment (G-E) interplay on drug use and HIV-related behavior. The proposed continuation augments CTAPS' scientific agenda to better address racial disparities in drug use and HIV-related behavior that affect rural African Americans. Emerging research suggests that exposure to chronic stress affects the functioning of inflammatory, neuroendocrine, and neurocognitive systems beginning in childhood and adolescence. The negative consequences of chronic stress affect health-related behaviors and forecast chronic diseases of aging. Emerging evidence suggests that these processes also may affect youth and young adults' development of drug misuse and HIV related behavior. The Center will sponsor a new generation of research on (a) the neuroendocrine, inflammatory, and neurocognitive pathways through which exposure to stress among rural African American youth and young adults creates vulnerabilities to drug use and HIV-related behavior, (b), the malleable risk and protective processes that affect underlying vulnerability mechanisms , and (c) the translation of findings into new and refined preventive interventions for youth in general and rural African American youth in particular. The CTAPS will pursue these scientific goals via providing infrastructure for three support cores (Inflammation/Neuroendocrine, Neurocognitive, Biostatistics) that will enrich data from data from Core projects and pilot projects and a Pilot Core. CTAPS will facilitate communication among Center-affiliated investigators, support core directors, and core project Pis; oversee administration of Center-wide budgets and operations; provide infrastructure and administrative support for three support cores and a Pilot Core. CTAPS will spur progress via a transdisciplinary work group system designed to facilitate transdisciplinary collaboration and to organize the allocation of Center resources and disseminate research findings to multiple stakeholders including researchers, policy makers, educational organizations, and the public.