Functional MRI Core Facility

协议号93-M-0170，NCT00001360 空间利用率： 功能磁共振成像设备(FMRIF)目前占地约4800平方英尺。FT空间，划分为扫描仪机架、控制室和电子/机房，用于核磁共振中心内的3TA、3Tb、3TC、3TD和7T核磁共振扫描仪，以及位于FMRIF/SFIM套房核磁共振中心上方二楼的办公空间(总面积约1400平方英尺，包括共享的会议空间)。 FMRIF的工作人员(目前是14个全职职位)包括：设施主任、维持扫描仪运行的三名科学家、六名核磁共振技术员、一名信息技术专家、一名程序员、一名技术实验室经理和一名实验室行政经理。 功能磁共振成像设施支持30多名首席调查人员的研究，总共翻译成300多名研究人员。目前有70多项研究方案在使用FMRIF扫描仪。每台扫描仪的预定工作时间为每周105小时。 自2000年成立至2016年8月，共有1069份来自内部调查人员的同行审查出版物使用了从FMRIF核心设施获得的数据。总数分布在NIMH的716篇论文、NINDS的257篇论文和其他研究所的96篇论文中。这些论文总共被引用了95,390次，总的h指数为152。换句话说，使用FMRIF的152篇论文至少被引用了152次。 项目： 我们在3TD上完成了高密度(128通道)EGI MRI兼容系统的安装，并培训了MRI技术人员。该系统目前正在用于3TD的氯胺酮的试点研究，以及协助Leo Cohens小组进行的一项研究，该研究结合了静息脑磁图和静息EEG/fMRI在中风康复中的作用。 Jan Varada组装了一条MRI质量控制处理流水线，该流水线可能用于确保在组装神经成像数据库时保持恒定的高质量数据质量。 7T PTX项目的标准工作流程已经建立，正在准备提交，以允许人类使用8Tx/32Rx系统(与Jeff Duyn小组合作)。 新的高性能图像重建系统安装在7T上，现在允许常规使用多波段、多回声(以前是禁止的)。我们已经演示了常规的2STR，1.1 mM的iso GE-EPI(100切片)。我们已经测试并安装了来自CMRR、MGH和马斯特里赫特的多波段序列。 我们在所有西门子扫描仪上安装并测试了明尼苏达大学磁共振研究中心的多波段序列。这些序列现在被常规用于3TD for LBC协议。 我们已经获得了用于GE MR750平台的斯坦福大学多波段EPI序列。我们正在将其移植到Epic 22.x上，以便在3TC上使用。 多亏了Vinai Roopchansingh的工作，我们已经发布了基本的GE(管弦乐队)原始数据到ISMRM-RD转换器。 我们已经将NIH-EPI(支持多回波)移植到PRISMA。该序列在NIH的研究人员中得到了广泛的使用，并正被分发(作为西门子C2P序列)到其他地点。我们还将NIH-3D-EPI(即分段3D EPI)移植到西门子Prisma平台上。这是现在使用的德意志集团(帕斯卡尔·萨蒂)，并正在分发(作为西门子C2P序列)到其他地点。

Protocol number 93-M-0170, NCT00001360 Space Utilization: The Functional MRI Facility (FMRIF) currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3TA, 3TB, 3TC, 3TD, and 7T MRI scanners located within the NMR center and office space on the second floor above the NMR center in the FMRIF/SFIM suite (approximately 1400 sq ft total, including shared conference space). The FMRIF staff (currently 14 full- time positions) consists of: the facility director, three staff scientists to keep the scanners running, six MRI technologists, an information technology specialist, a programmer, a technical laboratory manager, and an administrative laboratory manger. The functional MRI facility supports the research of over 30 Principal Investigators translating to over 300 researchers overall. Over 70 research protocols are active and making use of FMRIF scanners. Each scanner has scheduled operating hours of 105 hours per week. Since its inception in 2000 until August 2016, a total of 1069 peer-reviewed publications from intramural investigators have used data acquired in the FMRIF core facility. The total is distributed among 716 papers from NIMH, 257 papers from NINDS, and 96 from the other institutes. These papers have been cited a total of 95,390 times for a combined h-index of 152. In other words, 152 papers using the FMRIF have been cited at least 152 times. Projects: We completed installation of the high-density (128 channel) EGI MRI compatible system on 3TD and trained MRI technologists. The system is currently being used in pilot studies of ketamine on 3TD as well as a assisting with a study with Leo Cohens group that combines resting MEG and resting EEG/FMRI in stroke rehabilitation. Jan Varada has assembled an MRI quality control processing pipeline that will likely be used for making sure that the data quality remain of a constant high quality as the neuroimaging database becomes assembled. A standard workflow for the 7T pTX project has been established and submission is in preparation to allow human use of the 8Tx/32Rx system (in collaboration with the Jeff Duyn group). A new high-performance image reconstruction system was installed on the 7T that now permits routine use of multi-band, multi-echo (prohibitive before). We have demonstrated routine 2s TR, 1.1mm iso GE-EPI (100 slices). We have tested and installed multi-band sequences from CMRR, MGH and Maastricht. We installed and tested the Center for Magnetic Resonance Resaerch (University of Minnessota) Multi-band sequences on all Siemens scanners. These sequences are now being used routinely on 3TD for LBC protocol. We have gained access to a Stanford multi-band EPI sequence for GE MR750 platform. We are in the process of porting it to Epic 22.x for use on 3TC. Thanks mostly to the work of Vinai Roopchansingh, we have published the base GE (Orchestra) Raw Data to ISMRM-RD converter. We have ported NIH-EPI (supports multi-echo) to Prisma. The sequence is in wide use with researchers at NIH, and is being distributed (as a Siemens C2P sequence) to other sites. We also ported NIH-3D-EPI (i.e. segmented 3D EPI) to Siemens Prisma plaform. This is now in use with the Reich group (Pascal Sati), and is being distributed (as a Siemens C2P sequence) to other sites.