Biostatistics Shared Resource

梅奥临床癌症中心生物统计共享资源(BSR)，由 丹尼尔·萨金特博士(自2001年以来)与MCCC调查人员进行了专业的统计合作 40多年来一直致力于发展和开展同行评议的癌症中心研究，包括 基础科学、临床试验、流行病学研究和其他转化性和教育性研究。这个 CCSG资金在BSR内的主要用途是支持试点项目的统计协作，用于 协助研究人员开发已获批准的研究项目，这些项目不是以其他方式资助的，而是领先的 用于外部资金，并支持获得批准的MCCC统计协作的意外需求 项目。资金主要用于保护与MCCC合作的关键教职员工的FTE 免费成员；还提供资金来挑选高级MS统计人员从事经批准的MCCC的工作 项目。在目前的赠款期间，BSR成功地从战略上稳固地建立了高 维度基因组和蛋白质组数据分析，并在所有3个MCCC校区都有强大的存在。BSR 学院包括临床试验设计、生存分析、高维统计方法研究方面的负责人 数据、统计遗传学、生活质量研究和替代终点。 BSR有三个重点领域(团队)捆绑在一起，形成一个组织良好、高效的核心。它们是：(I)a 临床试验团队负责癌症临床试验、相关的翻译研究以及患者和 公共教育研究项目，(11)人口科学/计算基因组学小组负责 针对高维数据分析和癌症的统计协作和数据管理支持 观察性研究，包括遗传和分子流行病学，以及(Iii)生活质量小组 负责为MCCC调查人员提供协作、测量工具和分析 临床和心理社会干预对癌症患者、家庭、照顾者和其他人的影响。这个 BSR卓有成效，在833篇同行评议的出版物和合作中拥有作者资格 在本授权期内，美国国立卫生研究院或相当于美国国立卫生研究院的63项赠款。

The Biostatistics Shared Resource (BSR) of the Mayo Clinic Cancer Center (MCCC), under the leadership of Dr. Daniel Sargent, PhD (since 2001) has provided expert statistical collaboration with MCCC investigators for over 40 years for the development and conduct of peer-reviewed cancer center research encompassing basic science, clinical trials, epidemiologic research, and other translational and educational research. The primary usage of CCSG funds within the BSR is to support statistical collaboration on pilot projects, for assistance to investigators in developing approved research projects not otherwise funded but leading towards external funding, and to support unanticipated needs for statistical collaboration on MCCC approved projects. Funding is primarly provided to protect FTE of key faculty members to collaborate with MCCC members at no charge; funding is also provided to select senior MS statisticans for work on approved MCCC projects. In the current grant period the BSR has successfully and strategically firmly established high dimensional genomic and proteomic data analysis, and a robust presence at all 3 MCCC campuses. BSR faculty includes statistical methodological research leaders in clinical trial design, survival analysis, high-dimensional data, statistical genetics, quality of life research, and surrogate endpoints. The BSR has three focus areas (teams) tied together into a well-organized, efficient core. These are: (I) a Clinical Trials team responsible for cancer clinical trials, associated translational research, and patient and public education research projects, (11) a Population Science/Computational Genomics team responsible for statistical collaboration and data management support for high dimensional data analyses and cancer observational studies, including genetic and molecular epidemiology, and (III) a Quality of Life team responsible for collaboration, measurement tools, and analysis for MCCC investigators investigating the impact of clinical and psychosocial interventions on cancer patients, families, caregivers, and others. The BSR has been remarkably productive, with authorship on 833 peer reviewed publications and collaborations on 63 NIH or NIH-equivalent grants in the current grant period.