Predicting treatment response to onabotulinumtoxin-a in MS-related tremor: a combined clinical, electrophysiological and neuroimaging approach.

许多多发性硬化症(MS)患者都会出现上肢颤抖。我们之前已经证明，注射肉毒杆菌毒素(Botox)可以帮助减少震颤。这项研究旨在研究肉毒杆菌毒素对更大范围的多发性硬化症患者的影响，并将包括详细的MRI扫描和电震颤监测测试，以确定导致震颤的大脑潜在变化。这一结果将有助于将肉毒杆菌毒素用于治疗多发性硬化症患者的震颤。

Shaking (tremor) of the upper limbs occur in many people with multiple sclerosis (MS). We have previously shown that botulinum toxin (Botox) injections could help reduce tremor. This study aims to study the effect of Botox in a larger group of people with MS and will include detailed MRI scans and electrical tremor monitoring tests to define the underlying changes in the brain that causes tremor. The results will help make Botox available as a tremor treatment for people with MS.