Prevention of multi-drug resistant tuberculosis in a high prevalence setting: ‘Connecting the DOTS’ in Vietnam

耐多药结核病(MDR-TB)患者的密切接触者罹患该病的风险很高。V-Quin MDR-TB试验将评估口服抗生素(左氧氟沙星)在结核病患者的受感染家庭接触者中预防耐药结核病的有效性。来自越南10个省的家庭接触者将被随机分配接受为期6个月的左氧氟沙星或安慰剂治疗，然后进行为期两年的跟踪调查，看看他们是否患上了结核病。

The close contacts of people with multi-drug resistant tuberculosis (MDR-TB) have a high risk of developing the disease. The V-QUIN MDR-TB Trial will evaluate the effectiveness of an oral antibiotic (levofloxacin) in preventing drug resistant TB among infected household contacts of TB patients. Household contacts from 10 Provinces in Vietnam will be randomly allocated to receive six-months of either levofloxacin or a placebo, and then followed for two years to see if they develop tuberculosis.