Protein recognition of small RNAs in innate immunity

蛋白质-RNA相互作用在对病毒感染的免疫应答中至关重要。小干扰RNA（siRNA）是发现基因功能的重要工具，在治疗病毒感染和癌症方面具有巨大潜力，但也可以激活先天免疫系统。通过表征免疫系统传感器和所涉及的蛋白质-RNA相互作用的小RNA传感的决定因素，我们将获得新的见解siRNAs的设计用于临床。

Protein-RNA interactions are critical in the immune response to virus infections. Small interfering RNAs (siRNAs) are important tools in the discovery of gene function and have great potential for therapy against viral infections and cancer, but can also activate the innate immune system. By characterising the determinants of small RNA sensing by the sensors of the immune system and the protein-RNA interactions involved, we will gain new insights into the design of siRNAs for use in the clinic.