An Integrated Genomic and Epigenomic Approach to Dissect the Aetiology of Motor Neuron Disease

运动神经元病（MND）是一种破坏运动神经元的神经系统疾病，运动神经元控制肌肉活动，如行走。它影响40岁以上的人，大多数患者在3年内死亡。目前还没有专门的诊断方法，也没有治疗方法。我的目标是建立一个独立的研究小组，发现新的基因和表观遗传标记，并剖析它们在MND中的生物学功能。这一知识对于寻找有效的诊断、治疗和治愈MND至关重要。

Motor neuron disease (MND) is a neurological disease that destroys motor neurons, which control muscle activity, such as walking. It affects people >40 years old and most patients die within 3 years. There is no specific test for its diagnosis and there are no cures. I aim to build an independent research group to discover novel genes and epigenetic marks, and to dissect their biological function in MND. This knowledge is crucial for finding effective diagnosis, treatment and cure for MND.