An investigation into the molecular basis of MAIT cell recognition of vitamin B based metabolites
An investigation into the molecular basis of MAIT cell recognition of vitamin B based metabolites
批准号:
nhmrc : 1063587
负责人:
Dr Alexandra Corbett
金额:
$58.93万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31
中文摘要
粘膜相关不变T细胞(MAIT细胞)是人类体内含量丰富的T细胞,主要存在于胃肠道粘膜中。我们最近已经证明MAIT细胞可以被维生素B的代谢物激活。这项提议将研究MAIT细胞是如何“看到”维生素B代谢物的。这项研究将为能够调节MAIT细胞活动的新疗法铺平道路。
英文摘要
Mucosal associated invariant T cells (MAIT cells) are an abundant T-cell population in humans, that is found mostly in the gastrointestinal mucosa. We have recently shown that MAIT cells can be activated by metabolites of vitamin B. This proposal will investigate how the MAIT cells "see" vitamin B metabolites. This research will pave the way for novel therapeutics that can modulate MAIT cell activity.
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海外基金