The Janus Faces of G Protein-Coupled Receptors: Implications for Disease Mechanisms and Opportunities for Drug Discovery

G蛋白偶联受体(GPCRs)是生物体中最大的受体和药物靶标家族。目前，新药未能进入临床的主要原因是缺乏适当的药物效果(约.30%)。因此，我们需要更好地了解GPCRs是如何工作的，以及这与疾病有何关系。我们的计划利用与新陈代谢、炎症、心血管和中枢神经系统疾病的治疗相关的GPCR模型来解决这一知识鸿沟。

G Protein-Coupled Receptors (GPCRs) form the largest family of receptors and drug targets in living organisms. Currently, the major reason that new drugs fail to reach the clinic is lack of appropriate drug effect (approx. 30%). Thus, we need a better understanding of how GPCRs work and how this relates to disease. Our Program addresses this knowledge gap, using GPCR models that are relevant to treatment of metabolic, inflammatory, cardiovascular and central nervous system disease.