The mezzanine T cell response: intervening at the coal face

在最初的免疫反应中，淋巴结中的特化细胞告诉T细胞增殖;受刺激的T细胞离开并进入靶组织（例如流感病例中的肺）。我们描述了一种新的反应，即靶组织本身可以告诉T细胞进一步繁殖。靶组织中的这种反应揭示了改变免疫反应的新方法。这一点尤其重要，因为在许多疾病中，原发性淋巴结反应已经发生，因此无法进行治疗干预。

In an initial immune response, specialised cells in lymph nodes tell T cells to multiply; the stimulated T cells depart and enter target tissue (e.g. lung in the case of flu). We describe a new response whereby the target tissue itself can tell T cells to multiply further. This response in target tissues reveals a new way of altering immune responses. This is especially important as in many diseases, the primary lymph node response has already occurred, so cannot be therapeutically intervened.