The pathogenesis of distinct endophenotypes of asthma is underpinned by the collaborative activation of specific PRRs.

哮喘是一种由炎症引起的慢性呼吸道疾病。虽然哮喘患者可以根据肺部存在的炎性细胞的类型进行亚型划分，但目前还没有针对这些亚型的治疗药物。在这笔赠款中，我们将研究协调哮喘不同炎症性亚型发展的免疫过程。这些信息将帮助我们开发新的疗法，这些疗法将针对适当类型的炎症量身定做。

Asthma is a chronic airway disease caused by inflammation. Although asthmatics can be sub-typed based on the type of inflammatory cells present in the lungs, medication specific for the treatment of these sub-types is not yet available. In this grant we will investigate the immune processes that orchestrate the development of the distinct inflammatory sub-types of asthma. This information will help us develop new therapies that will be tailored to target the appropriate type of inflammation.