Astroglial remodelling of the interhemispheric midline is regulated by deleted in colorectal cancer (DCC) signalling and is required for corpus callosum formation

两个大脑半球之间的信息整合是通过一个叫做胼胝体的大束连接神经纤维进行的。DCC基因突变的人会出现镜像运动障碍，有些人会出现严重的大脑缺陷，胼胝体无法形成，但目前我们还不了解这种基因的功能。在本研究中，我们将探讨DCC如何在早期脑发育中调节胼胝体的形成和镜像运动障碍。

The integration of information between the brain hemispheres occurs via a large bundle of connecting nerve fibres called the corpus callosum. People with a genetic mutation in DCC display mirror movement disorder and some have a severe brain defect where the corpus callosum fails to form, but at present we don’t understand the function of this gene. In this study we will investigate how DCC functions in early brain development to regulate corpus callosum formation and mirror movement disorder.