Regulating astrocytosis for appropriate defence and repair of the brain after injury

在脑损伤后，一种旨在清理细胞碎片和维持组织完整性的炎症过程也会导致星形细胞疤痕，从生物化学角度阻碍神经修复。8周后，星形胶质细胞转变为支持细胞，然而一旦疤痕形成，修复就会被永久抑制。在这里，我们将测试生物材料优化必要炎症期时间的能力，通过更快地将星形胶质细胞转化为回归期来促进修复。

An inflammatory process, designed to clean up cell debris and maintain tissue integrity following brain insult, also results in an astrocytic scar that biochemically impedes nerve repair. After 8 weeks astrocytes switch to become supportive, however once a scar is formed repair is permanently inhibited. Here, we will test the ability of biomaterials to optimise the timing of the necessary inflammatory phase, to encourage repair by converting astrocytes to their tropic phase more rapidly.