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Cell-selective deletion of brain AT1A receptors in hypertension: Effect on blood pressure, increased ROS production and inflammation.

Cell-selective deletion of brain AT1A receptors in hypertension: Effect on blood pressure, increased ROS production and inflammation.
高血压患者大脑 AT1A 受体的细胞选择性缺失:对血压、ROS 产生增加和炎症的影响。
批准号:
nhmrc : 1029396
负责人:
Prof Andrew Allen
金额:
$38.56万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2015-12-31

项目摘要

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中文摘要
翻译
血管紧张素对血压的正常调节很重要,但也与心血管疾病有关。阻断血管紧张素的作用是治疗这些疾病的常用方法。血管紧张素受体功能缺失会降低血压。令人惊讶的是,网站(S)在机构中对这一下降负有责任的人还不清楚。我们将研究大脑中的血管紧张素受体在健康和心血管疾病中控制血压的作用。
英文摘要
Angiotensin is important for normal regulation of blood pressure but is also involved in cardiovascular diseases. Interruption of angiotensin’s actions is a common treatment of these diseases. Functional deletion of angiotensin receptors decreases blood pressure. Surprisingly the site(s) in the body responsible for this decrease are not known. We will examine the role of angiotensin receptors in the brain in the control of blood pressure in health and in cardiovascular disease.
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Unravelling the brain circuits linking emotions and heart rate variability.
  • 批准号:
    DP230103058
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $66.58万
  • 财政年份:
    2023
  • 负责人:
    Prof Andrew Allen
  • 依托单位:
Activity-based chemogenetics: a novel approach to modulating brain function
  • 批准号:
    DP210102546
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $46.12万
  • 财政年份:
    2021
  • 负责人:
    Prof Andrew Allen
  • 依托单位:
Central neural circuits subserving nutrient–activated thermogenesis - the basis of post prandial energy expenditure
  • 批准号:
    nhmrc : GNT1145144
  • 项目类别:
    Project Grants
  • 资助金额:
    $76.62万
  • 财政年份:
    2018
  • 负责人:
    Prof Andrew Allen
  • 依托单位:
Central neural circuits subserving nutrient–activated thermogenesis - the basis of post prandial energy expenditure
  • 批准号:
    nhmrc : 1145144
  • 项目类别:
    Project Grants
  • 资助金额:
    $51.81万
  • 财政年份:
    2018
  • 负责人:
    Prof Andrew Allen
  • 依托单位:
国内基金
海外基金
新型M4受体选择性拮抗剂的研究