Central, reflex and mechanical factors in the control of human breathing muscles.

我们将研究人类吸气肌的神经输出，以及它如何与呼吸的机械有效性相关，然后这种关系如何随着呼吸系统疾病（如慢性阻塞性肺病和阻塞性睡眠呼吸暂停）而改变。我们还将研究脊髓损伤患者呼吸肌的脊髓反射连接。这项工作有望对呼吸的基本控制以及它如何随疾病而变化有新的认识。

We will study the neural output to human inspiratory muscles and how it is related to mechanical effectiveness for breathing and then how this relationship can change with respiratory disorders such as chronic obstructive pulmonary disease and obstructive sleep apnoea. We will also examine the spinal reflex connections of human breathing muscles in people with spinal cord injury. This work promises new understanding of the basic control of respiration and how it changes with disease.