Characterising the mutations, signatures, potential new therapeutic targets and biomarkers in malignant mesothelioma using whole genome analysis.

恶性间皮瘤是一种侵袭性肿瘤，主要发生在胸膜，是吸入石棉纤维的结果。目前还没有治愈恶性间皮瘤的方法。因此，迫切需要新的治疗方法。这种新方法需要对恶性间皮瘤的遗传病变有详细的了解。因此，我们将对一大批恶性间皮瘤患者进行全基因组测序，以确定间皮瘤相关的改变。

Malignant mesothelioma is an aggressive tumour that occurs principally in the pleura as a consequence of inhaling asbestos fibres. Currently there is no cure for malignant mesothelioma. Thus new therapeutic approaches are desperately needed. Such new approaches will require a detailed understanding of the genetic lesions of malignant mesothelioma. Therefore we will perform whole genome sequencing of a large cohort of malignant mesothelioma patients to identify mesothelioma-related alterations.