Application of next generation sequencing to address clinical problems in cancer

应用下一代测序解决癌症临床问题

• 批准号: nhmrc : 1112113
• 负责人: Dr Nicola Waddell
• 金额: $ 31.68万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/application-generation-sequencing-problems-cancer/663205
• 关键词: Application; next; generation; sequencing; address

Cancer is the cause of 1 in 8 deaths worldwide. Cancer occurs due to errors or mutations in the DNA of normal cells. The mutations may cause the cells to grow incorrectly and become cancer. I will identify the mutations or errors in tumour cells. This will tell us: i) How the tumour started and continued to grow ii) How to treat the tumour cells to kill the cancer The work will involve a variety of cancer types including mesothelioma, melanoma, oesophageal, pancreatic and breast cancer.

全世界每8例死亡中就有1例是癌症造成的。癌症的发生是由于正常细胞DNA的错误或突变。这些突变可能会导致细胞生长不正常而变成癌症。我将识别肿瘤细胞中的突变或错误。这将告诉我们：i)肿瘤是如何开始和继续生长的ii)如何治疗肿瘤细胞以杀死癌症。这项工作将涉及各种类型的癌症，包括间皮瘤、黑色素瘤、食道癌、胰腺癌和乳腺癌。