Defining the genomic and therapeutic landscape of familial breast cancer

定义家族性乳腺癌的基因组和治疗前景

• 批准号: nhmrc : GNT1080985
• 负责人: Dr Nicola Waddell
• 金额: $ 111.5万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-genomic-therapeutic-breast-cancer/1345378
• 关键词: Defining; genomic; therapeutic; landscape; familial

As a cancer develops it accumulates alterations (mutations) in its DNA. Some of these alterations lead to enhanced tumour growth, whilst others provide insight into normal processes that have gone wrong to enable the tumour to arise. We will use DNA sequencing and mathematical approaches to characterise these alterations and to identify therapeutic targets in breast tumours arising in patients with an inherited predisposition to develop cancer.

随着癌症的发展，它会积累其DNA的改变（突变）。其中一些改变导致肿瘤生长增强，而另一些改变则提供了对正常过程的深入了解，这些正常过程出现了错误，使肿瘤得以出现。我们将使用DNA测序和数学方法来验证这些改变，并确定乳腺肿瘤的治疗靶点，这些肿瘤是在具有遗传性癌症易感性的患者中产生的。