Characterization of the chloroquine resistance transporter of the malaria parasite

疟疾寄生虫是一种单细胞生物，它侵入宿主的红细胞。这个项目的目的是描述寄生虫对抗疟疾药物氯喹产生耐药性的机制。耐药性是由单个蛋白质的微小变化引起的，但潜在的机制尚不清楚。该项目的结果将使我们对日益普遍的抗疟药物耐药性现象的理解取得重大进展。

The malaria parasite is a single-celled organism which invades the red blood cells of its host. The aim of this project is to characterise the mechanism by which parasites have become resistant to the antimalarial drug chloroquine. Resistance is conferred by small changes in a single protein, but the underlying mechanism is not known. The results of this project will constitute a major advance in our understanding of the increasingly widespread phenomenon of antimalarial drug resistance.