Developing the toolbox of compounds that target acid-sensing proteins

本项目旨在研究酸敏感蛋白及其调节化合物之间的相互作用。动物，包括人类，必须感知环境酸度的变化，才能成功地与周围世界互动。该项目的预期结果包括更好地了解这些蛋白质的哪些区域检测酸度，并开发调节蛋白质功能的新化合物。这将提高我们对酸感知生理过程的基本认识。这有望提供显著的效益，通过帮助农用化学品和镇痛药物的潜在发展，调节酸感蛋白的功能，从而通过这些新产品为澳大利亚带来经济效益。

This project aims to examine the interaction between acid-sensing proteins and their modulatory compounds. Animals, including humans, must sense changes in environmental acidity to successfully interact with the surrounding world. Expected outcomes of the project include a better understanding of which regions of these proteins detect acidity, and to develop new compounds that modulate the proteins’ function. This would advance our fundamental knowledge in the physiological process of acid sensing. This expects to provide significant benefits, by aiding the potential development of agrochemicals and pain-relieving medications that regulate acid-sensing protein function, resulting in economic benefit to Australia via these new products.