Characterization of the Type IX secretion system in Porphyromonas gingivalis

牙周炎与关键病原体牙龈卟啉单胞菌有关。我们已经确定了一种新的蛋白质分泌机器，由牙龈卟啉单胞菌中的至少12种组分组成，其将细菌的主要毒力因子转运到细胞表面并将其附着到外膜上。我们的目标是确定这12个成分中每个成分的空间排列和具体作用，从而为未来针对这种疾病的治疗提供目标。

Periodontitis is associated with the keystone pathogen Porphyromonas gingivalis. We have identified a novel protein secretion machine comprised of at least 12 components in P. gingivalis which transports the bacterium's major virulence factors to the cell surface and attaches them to the outer membrane. We aim to determine the spatial arrangement and specific role of each of these 12 components and thereby provide targets for future treatments against this disease.