300 MHz NMR spectrometer for "walk on" use in chemistry research at the University of Winnipeg

来自海洋和陆地来源的天然产物显示出有趣的抗微生物、抗病毒和抗炎活性。这些生物活性使天然产品成为发现新药物的重要来源，市场上60%以上的药物都是天然产品。例如，从太平洋紫杉树短叶红豆杉中分离出的紫杉醇是一种有效的抗癌剂。生物活性天然产物的结构鉴定是该研究的重要步骤之一。核磁共振（NMR）光谱仪是获取复杂化合物结构解析中所需的一维和二维光谱数据（1H-，13 C，COSY，TOCSY，HMQC，HMBC，NOESY）的必要工具之一。这种化学表征有助于设计新分离的生物活性天然产物的合成。这台机器也用于研究无机和有机化学中的反应机理。它被认为是化学部门中最重要的工具之一，以促进化合物的结构表征。 温尼伯大学化学系不再提供功能性NMR。 因此，我们正在申请资金购买300 MHz NMR，以促进我们的各种NSERC资助的研究计划。

Natural products derived from marine and terrestrial sources exhibit interesting anti-microbial, anti-viral and anti-inflammatory activities. These bioactivities make natural products as an important source for the discovery of new pharmaceutical agents and more than 60% of the drugs available on the market are of natural product origin. For instance, Taxol, isolated from pacific yew tree Taxus brevifolia, is a potent anti-cancer agent. One of the most important steps in this research involves the structure elucidation of bioactive natural products. Nuclear Magnetic Resonance (NMR) spectrometer is one of the required tools to acquire one- and two-dimensional spectral data (1H-, 13C, COSY, TOCSY, HMQC, HMBC, NOESY) used in the structure elucidation of complex chemical compounds. This chemical characterization helps in designing the synthesis of newly isolated bioactive natural products. This machine is also used to study the reaction mechanisms in inorganic and organic chemistry. It is considered as one of the most important instruments in chemistry departments to facilitate the structural characterization of chemical compounds.  The Department of Chemistry, University of Winnipeg no longer has a  functional NMR available.  Therefore, we are requesting funds to acquire a 300 MHz NMR to facilitate our various NSERC funded research programs.