Regulation of arthritis and skin inflammation by annexin-1

膜联蛋白-1是一种类固醇物质，它介导类固醇的许多作用。我们的研究将揭示annexin-1是否会减少炎症和免疫反应，其次，确定annexin-1在免疫反应中调节的物质。如果发现膜联蛋白-1介导类固醇的免疫调节作用，则其参与类固醇的有益作用的能力可能在关节炎和其他炎性疾病的治疗中具有重要影响。

Annexin-1, an antiinflammatory substance, mediates many of the actions of steroids. Our studies will reveal whether annexin-1 will reduce inflammatory and immune responses, and secondly, determine the substances regulated by annexin-1 in immune responses. If annexin-1 is found to mediate the immune regulatory effect of steroids, its capacity to be involved in the beneficial effect of steroids may have an important impact in treatment of arthritis and other inflammatory diseases.