Regulation of innate immunity and tumour progression by activating transcription factor 3

toll样受体（TLRs）在先天免疫应答中发挥重要作用，并通过炎症途径参与启动肿瘤发生。我们已经证明转录因子ATF3是TLR信号传导的负调节因子。我们将研究ATF3活性的调节如何影响炎症反应和肿瘤进展。这将为设计治疗癌症的试剂提供分子基础。

Toll-like receptors (TLRs) play an essential role in innate immune responses and are involved in initiating tumourigenesis via inflammatory pathways. We have shown that the transcription factor ATF3 is a negative regulator of TLR signalling. We will study how modulation of the activity of ATF3 affects the inflammatory response and tumour progression. This will provide a molecular basis on which to design therapeutic reagents for the treatment of cancer.