Breath by breath gas analysis system

本提案要求SensorMedics Vmax 29 Encore心肺系统。这种专门的设备用于测量人体吸入和呼出的氧气和二氧化碳的量；这可以在休息或运动时进行。该设备是专门的，因为它为每次呼吸提供信息，而类似的系统需要收集和平均几次呼吸才能提供准确的结果。所要求的设备非常灵敏，因此它可以用来测量呼吸的快速变化，这些变化提供了非常有价值的信息，关于身体如何应对其需要使用能量的变化。作为一名建立研究项目的新调查员，我的工作重点是儿童对运动的反应。这项工作的主要目的是了解是什么使体育活动对儿童的健康有益。所要求的设备对我的工作至关重要，因为它提供了一种非侵入性的方法来测量儿童对运动的反应的许多方面，以及生长如何影响这些反应。有了这个设备，我可以a)通过直接测量运动中可以消耗多少氧气来测量健康水平；B)通过测量氧气和二氧化碳之间的关系来估计运动中肌肉使用的能量来源；c)通过了解身体消耗氧气的速度，了解有多少血液被输送到工作肌肉。了解正在成长的儿童所有这些过程的能力，为了解哪些因素有助于控制这些反应提供了一个极好的方法。这一信息将对其他领域的研究人员非常有用，这些研究人员对有规律的体育活动如何转化为健康感兴趣。所要求的设备将为与该领域的其他专家一起工作创造许多可能性，并为目前无法获得类似设备的我的学生和访问学者提供培训的重要工具。我们的实验室是世界上为数不多的致力于儿童和运动研究的实验室之一，这些设备将使我们保持在令人兴奋的新发现的前沿。

This proposal is requesting the SensorMedics Vmax 29 Encore Cardiopulmonary System.  This specialized equipment is used in humans to measure how much oxygen and carbon dioxide is breathed in and out; this can be done at rest or during exercise.  The equipment is specialized because it gives this information for each breath that is taken whereas similar systems need to collect and average several breaths to provide accurate results.  The requested equipment is very sensitive so it can be used to measure very rapid changes in breathing and these changes provide very valuable information on how the body responds to changes in its need to use energy.  As a new investigator building a research program, my work focuses on children's responses to exercise.  The main objective of this work is to understand what makes physical activity good for children's health.  The requested equipment is essential to my work as it provides a non-invasive method to measure many aspects of a child's response to exercise and how growth affects these responses.  With this equipment, I can a) measure fitness levels by directly measuring how much oxygen can be consumed during exercise; b) estimate what energy sources muscles use during exercise by measuring the relationship between oxygen and carbon dioxide; and c) gain some insight into how much blood is being delivered to the working muscle by knowing how quickly oxygen is being used by the body.  The ability to understand all of these processes in children who are growing provides an excellent way to learn what factors help control these responses.  This information will be very useful for researchers in other areas interested in how regular physical activity translates into health.  The requested equipment will create numerous possibilities to work together with other experts in the field and provide an essential tool for training of my students and visiting scholars who are currently restricted in their access to similar equipment.  Our laboratory is one of only a few in the world devoted to the study of children and exercise and this equipment will keep us at the leading edge of exciting new discoveries.