Research Fellowship: Understanding G protein-coupled receptors (GPCRs)

该项目的重点是药物作用于G蛋白偶联受体（GPCRs），这是最大的一类药物靶点。它基于申请人的关键发现，即GPCR上的新位点可以被小分子以选择性方式靶向，从而最大限度地减少副作用并最大限度地提高治疗效果。由于这种方法可以在大多数GPCR家族中发挥作用，因此与制药业和GPCR相关疾病（如精神分裂症和糖尿病）的相关性非常高。

This project focuses on drug action at G protein-coupled receptors (GPCRs), the largest class of drug targets. It builds on key discoveries by the applicant that novel sites on GPCRs can be targeted by small molecules in a selective manner, thus minimizing side effects and maximizing therapeutic efficacy. Because this approach can work across most GPCR families, the relevance to the pharmaceutical industry and GPCR-related diseases, such as schizophrenia and diabetes, is very high.