Reversing oxidative inhibition of the Na-K pump by beta3 adrenergic agonists: implications for heart failure therapy

心力衰竭是一种以心脏泵功能下降为特征的衰弱性疾病。心肌细胞中Na+水平升高和氧化应激增加是其重要原因。虽然传统的抗氧化剂在治疗中没有用，但我们发现一组旨在诱导减肥的药物可以逆转将Na+泵出心脏细胞的机制的氧化抑制。将检查这些药物对Na+泵送机制和心力衰竭的影响。

Heart failure is a debilitating condition characterised by a decreased heart pump function. Raised Na+ levels and increased oxidative stress in cardiac cells are important in its causation. While traditional antioxidants are not useful in treatment, we have found that a group of drugs designed to induce weight loss can reverse oxidative inhibition of the mechanism that pumps Na+ out of heart cells. The effect of these drugs on the Na+ pumping mechanism and heart failure will be examined.