Reversing the biomechanical dysregulation of cancer cell signalling to improve targeted therapies

抗癌药物的有限成功取决于许多因素，包括肿瘤的物理性质（硬度）。特别是肿瘤是软的还是硬的会影响它对治疗的反应。结合经典生物学和工程学来生成模拟肿瘤的3D模型，以及尖端的成像技术，我们将确定如何将肿瘤的物理特性与已经批准的癌症药物结合起来，以改善治疗和患者的预后。

The limited success of cancer drugs is dependent on many factors including the physical properties (stiffness) of a tumour. In particular whether a tumour is soft or stiff affects how it responds to treatment. Combining classical biology with engineering to generate 3D models that mimic tumours, along with cutting-edge imaging technology, we will determine how we can target the physical properties of tumours together with already approved cancer drugs to improve treatment and patient outcome.