Role of bacteriophage-encoded streptodornase in invasive disease caused by diverse group A streptococcal M serotypes.

据估计，化脓性链球菌（A组链球菌，GAS）每年在全世界造成约7亿例自限性咽喉或皮肤感染。侵袭性气体疾病约发生1-1000例，相关死亡率为25%。我们最近发现，一种病毒感染可以重新编程GAS，使其具有侵袭性疾病倾向。我们将调查这种现象是否普遍存在，以便了解这一过程并开发未来的治疗方法。

Streptococcus pyogenes (group A streptococcus, GAS) is estimated to cause ~700 million cases of self-limited throat or skin infection each year worldwide. Invasive GAS disease occurs in approximately 1-1000 cases, with associated mortality of 25%. We have recently discovered that a viral infection can reprogram GAS for invasive disease propensity. We will investigate whether this phenomenon is widespread, in order to understand this process and develop future therapeutics.