The role of clathrin in the spindle assembly checkpoint and as an anti-cancer target

细胞分裂产生两个子细胞。调节有丝分裂的蛋白质的不正确定位和修饰会导致可能导致癌症的错误。除了使用一种独特的机械外，有丝分裂还使用参与非细胞周期途径的蛋白质。这个项目研究的作用在有丝分裂的一个这样的蛋白质：网格蛋白。我们将确定铅网格蛋白抑制化合物，有潜在的抗癌特性，最终被用作化疗药物。

Cell division produces two daughter cells. Incorrect localisation and modification of proteins that regulate mitosis cause errors that can lead to cancer. As well as using a unique machinery mitosis uses proteins involved in non-cell cycle pathways. This project investigates the role during mitosis of one such protein: clathrin. We will identify lead clathrin inhibitory compounds, pitstops, that have potential anti-cancer properties, ultimately to be used as a chemotherapy agent.