Role of condensin in chromosome organisation and regulation

当一个细胞分裂时，它的遗传物质（DNA）必须被复制并均匀地分离到每个子细胞中。我们的DNA被组织成许多被称为染色体的长单位。为了使我们的遗传物质忠实地分离成两个子细胞，染色体必须紧密结合近一万倍。一个关键成分是凝聚蛋白，我们的目标是找出凝聚蛋白如何指导哺乳动物染色体的组织和压实。

When a cell divides, its hereditary material (DNA) must be copied and equally segregated into each daughter cell. Our DNA is organised into a number of long units known as chromosomes. In order for our genetic material to be faithfully segregated into two daughter cells, the chromosomes must compact nearly 10,000 fold. A key component is condensin and we aim to find out how condensin directs the organisation and compaction of the mammalian chromosome.