The role of the homeobox transcription factor Hhex in haematopoiesis and leukaemia

我们已经表明，造血表达的同源异型盒（Hhex）蛋白在免疫细胞的发育中起着重要作用。此外，Hhex是急性髓系白血病（AML）发展和维持所必需的。该项目将进一步研究Hhex在人类AML中的需求，可能在这种预后不良的癌症亚型中确定新的治疗靶点。此外，我们将确定Hhex的关键辅助因子和靶点，揭示新的治疗策略。

We have shown that the Haematopoietically expressed homeobox (Hhex) protein plays important roles in development of immune cells. In addition, Hhex is required for development and maintenance of Acute Myeloid Leukemia (AML). This project will further investigate the requirement of Hhex in human AML, potentially identifying a new therapeutic target in this poor-prognosis cancer subtype. In addition, we will identify critical cofactors and targets of Hhex, revealing new therapeutic strategies.