Role of lncRNA IDH1-AS1 in regulating c-Myc driven-glycolysis and tumorigenesis

人们认为，了解癌症代谢将揭示可以在临床上利用的漏洞。事实上，与大多数正常细胞相比，癌细胞利用不同的燃料来维持增殖并适应其环境。在此，我们发现了一种调节关键代谢酶IDH1的分子开关，并表明这控制了肿瘤生长。鉴于这种开关可能在50%的癌症中是活跃的，我们预计我们的工作将对许多癌症类型具有重要意义。

It is thought that understanding cancer metabolism will reveal vulnerabilities that can be exploited in the clinic. Indeed, compared to most normal cells, cancer cells utilise different fuels to sustain proliferation and to adapt to their environment. Herein we have discovered a molecular switch that regulates the key metabolic enzyme IDH1 and show this controls tumour growth. Given this switch may be active in 50% of cancers we anticipate our work will have significance to many cancer types.