The Role of the Osteoblast in Mediating Glucocorticoid-Induced Metabolic Dysfunction

就治疗的患者数量和适应症而言，糖皮质激素(GC)超过了大多数其他药物。因此，预防或减轻GC对燃料代谢的有害影响具有重要的临床意义。我们的研究将创造关于GC诱导的糖尿病和骨质疏松症机制的新知识，并将有助于开发新的方法，这些方法对于解决GC诱导的疾病这一紧迫的医学问题至关重要。

Glucocorticoids (GC) exceed most other drugs in terms of numbers of patients treated and indications. Preventing or attenuating the deleterious effects of GC on fuel metabolism is therefore of great clinical significance. Our studies will create new knowledge regarding the mechanisms of GC-induced diabetes and osteoporosis, and will contribute to the development of new approaches that are essential to tackle the pressing medical problem of GC-induced disease.