The role of phosphorylation and signalling for invasion of Plasmodium falciparum into human erythrocytes.

控制恶性疟原虫疟疾入侵红细胞的细胞内信号尚不清楚。这可能是钙依赖性磷酸化导致蛋白质级联的招募和激活。本研究结合了活的恶性疟原虫分裂子纯化的突破和磷酸化状态的蛋白质组学分析来评估细胞内信号。预计所确定的过程将是恶性疟原虫独有的，并且可被药物靶向。

The intracellular signals that govern Plasmodium falciparum malaria invasion of the red blood cell are poorly understood. It is likely calcium dependent phosphorylation leads to recruitment and activation of a cascade of proteins. This study combines a break-through in purification of viable P. falciparum merozoites with proteomic analysis of phosphorylation states to assess intracellular signalling. It is expected the processes identified will be unique to P. falciparum and targetable by drugs.